Higher doses of Botox might result in bone loss, shows study

Botox injections that used to handle jaw and facial ache do not result in clinically significant changes in jaw bone when used in short term and in low doses, according to researchers at NYU College of Dentistry. However, they discovered proof of bone loss when higher doses have been used.

The researchers, whose findings are revealed in the Journal of Oral Health Rehabilitation, call for further clinical research to track bone- and muscle-related changes with long-term use of Botox for TMJD, or temporomandibular muscle and joint problems.

TMJDs are a group of common ache circumstances that happen within the jaw joint and surrounding muscles, with the most common kind involving the muscles responsible for chewing.

Whereas many people handle their TMJD symptoms with conservative treatments like jaw workout routines, oral home equipment, dietary changes, and pain killers, some don’t respond to these treatments.

Botox (or botulinum toxin), an FDA-approved injectable drug identified for its wrinkle-reducing capabilities, is authorized to deal with certain muscle and ache disorders, including migraines.

It works partially by temporarily paralyzing or weakening muscles. In the U.S., a Phase three medical trial is presently underway to review the use of Botox to deal with TMJD, however, in the meantime, it’s increasingly being used off-label.

So far, small research using Botox to deal with TMJD in people have had combined results. In animal research, Botox injections in jaw muscles have led to major bone loss within the jaw.

Botox injection

That is considered due to the muscles not being used to exert the force needed for bone remodeling, but Botox may have a direct effect on bone resorption, the method of breaking down bone tissue.

The NYU study included 79 women with TMJD affecting their facial muscles: 35 of whom acquired Botox injections (between two and 5 rounds in the past year) and 44 who weren’t treated with Botox however might have used different TMJD treatments. Using specialized CT scans, the researchers measured contributors’ jaw bone density and volume.

The researchers discovered that jaw bone density and volume have been related between women who had Botox injections to treat their TMJD and those that didn’t.

Whereas most study participants got comparatively low doses of Botox–smaller than in most medical trials for TMJD–individuals who acquired higher doses of Botox have been more likely to have lower bone density.

Raphael and her colleagues recommend that extra human research be performed to better understand the influence of the long-term use of Botox on jaw muscles and bones–and whether or not it simply reduces muscle power on the bone or additionally performs a direct position in altering bone resorption.

“Should Botox obtain regulatory approval for the therapy of TMJD, we’d suggest {that a} part IV study to be done using low-radiation CT and MRI to trace bone- and muscle-related changes with Botox use, analyzing both dose and long-term use,” said Raphael. “Except specialized imaging of muscle and bone are performed amongst patients who obtain Botox therapy over long periods, true cumulative effects will remain unknown.”